This paper explores the convergence of science, ethics, and theology, with a focus on how the concept of God can provide a moral compass for scientific innovation within the African cultural and philosophical landscape. Grounded in African ethical humanism and the theological framework of theonomous ethics, the research critically examines the tension between technological advancement and moral responsibility in African societies. Drawing on both qualitative content analysis and historical-theological methodology, this study interrogates the roles of indigenous spirituality and Christian theology in shaping an ethically responsive scientific culture. The research identifies core ethical dilemmas arising from unregulated technological innovation, such as bioethics, artificial intelligence, environmental degradation, and inequality in access to healthcare technologies. African scholars like John Mbiti, Kwame Gyekye, Mercy Oduyoye, and Emmanuel Asante have contributed significantly to discourse on African moral thought and theological ethics, laying the groundwork for contextualizing innovation within a value-laden framework.
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